Clopidogrel and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Clopidogrel and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Clopidogrel interacts with Fluconazole

Fluconazole inhibits CYP2C19, the enzyme required to convert clopidogrel to its active thiol metabolite, reducing platelet inhibition.

What you should do

Consider an alternative antifungal or a P2Y12 inhibitor not dependent on CYP2C19 activation (e.g. prasugrel or ticagrelor) in patients at high thrombotic risk.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C19, the enzyme required to convert clopidogrel to its active thiol metabolite, reducing platel...

Action

Consider an alternative antifungal or a P2Y12 inhibitor not dependent on CYP2C19 activation (e.g. prasugrel or ticagrelo...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clopidogrel and Fluconazole together?

With caution. Consider an alternative antifungal or a P2Y12 inhibitor not dependent on CYP2C19 activation (e.g. prasugrel or ticagrelor) in patients at high thrombotic risk.

What is the severity of this interaction?

The interaction between Clopidogrel and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP2C19, the enzyme required to convert clopidogrel to its active thiol metabolite, reducing platelet inhibition.

What should I do if I'm prescribed both?

Consider an alternative antifungal or a P2Y12 inhibitor not dependent on CYP2C19 activation (e.g. prasugrel or ticagrelor) in patients at high thrombotic risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.