Codeine and Paroxetine: Drug Interaction Guide

Quick answer: This combination requires caution. Codeine and Paroxetine can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Codeine interacts with Paroxetine

Paroxetine strongly inhibits CYP2D6, which converts codeine to its active metabolite morphine. Analgesic efficacy may be reduced or absent.

What you should do

Use an analgesic not dependent on CYP2D6 activation, such as morphine or non-opioid options when appropriate. Monitor pain control if the combination is used.

Key facts

Severity

Moderate — caution required

Mechanism

Paroxetine strongly inhibits CYP2D6, which converts codeine to its active metabolite morphine. Analgesic efficacy may be...

Action

Use an analgesic not dependent on CYP2D6 activation, such as morphine or non-opioid options when appropriate. Monitor pa...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Codeine and Paroxetine together?

With caution. Use an analgesic not dependent on CYP2D6 activation, such as morphine or non-opioid options when appropriate. Monitor pain control if the combination is used.

What is the severity of this interaction?

The interaction between Codeine and Paroxetine is classified as Moderate — caution required. Paroxetine strongly inhibits CYP2D6, which converts codeine to its active metabolite morphine. Analgesic efficacy may be reduced or absent.

What should I do if I'm prescribed both?

Use an analgesic not dependent on CYP2D6 activation, such as morphine or non-opioid options when appropriate. Monitor pain control if the combination is used. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.