Colchicine and Cyclosporine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Colchicine and Cyclosporine unless specifically directed by your doctor.
How Colchicine interacts with Cyclosporine
Cyclosporine inhibits both CYP3A4 and P-glycoprotein, dramatically increasing colchicine exposure and the risk of life-threatening neuromyopathy and bone marrow suppression.
What you should do
Avoid colchicine in transplant patients on cyclosporine when possible; if necessary for acute gout, use a single 0.6 mg dose and do not repeat for at least 3 days, with renal-function adjustment.
Key facts
Severity
Major — avoid combination
Mechanism
Cyclosporine inhibits both CYP3A4 and P-glycoprotein, dramatically increasing colchicine exposure and the risk of life-t...
Action
Avoid colchicine in transplant patients on cyclosporine when possible; if necessary for acute gout, use a single 0.6 mg ...
Frequently asked questions
Can I take Colchicine and Cyclosporine together?
No — this combination should generally be avoided. Avoid colchicine in transplant patients on cyclosporine when possible; if necessary for acute gout, use a single 0.6 mg dose and do not repeat for at least 3 days, with renal-function adjustment.
What is the severity of this interaction?
The interaction between Colchicine and Cyclosporine is classified as Major — avoid combination. Cyclosporine inhibits both CYP3A4 and P-glycoprotein, dramatically increasing colchicine exposure and the risk of life-threatening neuromyopathy and bone marrow suppression.
What should I do if I'm prescribed both?
Avoid colchicine in transplant patients on cyclosporine when possible; if necessary for acute gout, use a single 0.6 mg dose and do not repeat for at least 3 days, with renal-function adjustment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.