Cyclosporine and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Cyclosporine and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Cyclosporine interacts with Fluconazole

Fluconazole inhibits CYP3A4, decreasing cyclosporine metabolism. Cyclosporine exposure may increase, raising nephrotoxicity and hypertension risk.

What you should do

Monitor cyclosporine trough concentrations and renal function. Adjust cyclosporine dose as needed.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP3A4, decreasing cyclosporine metabolism. Cyclosporine exposure may increase, raising nephrotoxic...

Action

Monitor cyclosporine trough concentrations and renal function. Adjust cyclosporine dose as needed.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Fluconazole together?

With caution. Monitor cyclosporine trough concentrations and renal function. Adjust cyclosporine dose as needed.

What is the severity of this interaction?

The interaction between Cyclosporine and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP3A4, decreasing cyclosporine metabolism. Cyclosporine exposure may increase, raising nephrotoxicity and hypertension risk.

What should I do if I'm prescribed both?

Monitor cyclosporine trough concentrations and renal function. Adjust cyclosporine dose as needed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.