Cyclosporine and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Cyclosporine and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Cyclosporine interacts with Rifampicin

Rifampicin strongly induces CYP3A4 and P-glycoprotein, dramatically lowering cyclosporine concentrations and risking transplant rejection.

What you should do

Avoid combination if possible; if rifampicin is essential, increase cyclosporine dose substantially with frequent trough monitoring.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin strongly induces CYP3A4 and P-glycoprotein, dramatically lowering cyclosporine concentrations and risking tra...

Action

Avoid combination if possible; if rifampicin is essential, increase cyclosporine dose substantially with frequent trough...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Cyclosporine and Rifampicin together?

No — this combination should generally be avoided. Avoid combination if possible; if rifampicin is essential, increase cyclosporine dose substantially with frequent trough monitoring.

What is the severity of this interaction?

The interaction between Cyclosporine and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and P-glycoprotein, dramatically lowering cyclosporine concentrations and risking transplant rejection.

What should I do if I'm prescribed both?

Avoid combination if possible; if rifampicin is essential, increase cyclosporine dose substantially with frequent trough monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.