Erythromycin and Statins: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Erythromycin and Statins unless specifically directed by your doctor.
How Erythromycin interacts with Statins
Erythromycin is a CYP3A4 inhibitor that raises plasma concentrations of CYP3A4-metabolised statins (simvastatin, lovastatin, atorvastatin), increasing myopathy and rhabdomyolysis risk.
What you should do
Avoid erythromycin with simvastatin or lovastatin; if atorvastatin is required, use the lowest effective dose and monitor for muscle symptoms.
Key facts
Severity
Major — avoid combination
Mechanism
Erythromycin is a CYP3A4 inhibitor that raises plasma concentrations of CYP3A4-metabolised statins (simvastatin, lovasta...
Action
Avoid erythromycin with simvastatin or lovastatin; if atorvastatin is required, use the lowest effective dose and monito...
Frequently asked questions
Can I take Erythromycin and Statins together?
No — this combination should generally be avoided. Avoid erythromycin with simvastatin or lovastatin; if atorvastatin is required, use the lowest effective dose and monitor for muscle symptoms.
What is the severity of this interaction?
The interaction between Erythromycin and Statins is classified as Major — avoid combination. Erythromycin is a CYP3A4 inhibitor that raises plasma concentrations of CYP3A4-metabolised statins (simvastatin, lovastatin, atorvastatin), increasing myopathy and rhabdomyolysis risk.
What should I do if I'm prescribed both?
Avoid erythromycin with simvastatin or lovastatin; if atorvastatin is required, use the lowest effective dose and monitor for muscle symptoms. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.