Sirolimus and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Sirolimus and Voriconazole unless specifically directed by your doctor.
How Sirolimus interacts with Voriconazole
Voriconazole is a potent CYP3A4 inhibitor that increases sirolimus exposure up to 10-fold, with risk of nephrotoxicity, thrombocytopenia and hyperlipidemia.
What you should do
Concomitant use generally contraindicated. If essential, reduce sirolimus dose by 90% with daily trough monitoring. Consider isavuconazole as alternative antifungal.
Key facts
Severity
Major — avoid combination
Mechanism
Voriconazole is a potent CYP3A4 inhibitor that increases sirolimus exposure up to 10-fold, with risk of nephrotoxicity, ...
Action
Concomitant use generally contraindicated. If essential, reduce sirolimus dose by 90% with daily trough monitoring. Cons...
Frequently asked questions
Can I take Sirolimus and Voriconazole together?
No — this combination should generally be avoided. Concomitant use generally contraindicated. If essential, reduce sirolimus dose by 90% with daily trough monitoring. Consider isavuconazole as alternative antifungal.
What is the severity of this interaction?
The interaction between Sirolimus and Voriconazole is classified as Major — avoid combination. Voriconazole is a potent CYP3A4 inhibitor that increases sirolimus exposure up to 10-fold, with risk of nephrotoxicity, thrombocytopenia and hyperlipidemia.
What should I do if I'm prescribed both?
Concomitant use generally contraindicated. If essential, reduce sirolimus dose by 90% with daily trough monitoring. Consider isavuconazole as alternative antifungal. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.