Dasatinib and Omeprazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Dasatinib and Omeprazole unless specifically directed by your doctor.
How Dasatinib interacts with Omeprazole
Omeprazole persistently raises gastric pH, substantially reducing the pH-dependent dissolution and absorption of dasatinib.
What you should do
Avoid proton-pump inhibitors during dasatinib therapy. Use an appropriately separated antacid or another oncology-approved strategy.
Key facts
Severity
Major — avoid combination
Mechanism
Omeprazole persistently raises gastric pH, substantially reducing the pH-dependent dissolution and absorption of dasatin...
Action
Avoid proton-pump inhibitors during dasatinib therapy. Use an appropriately separated antacid or another oncology-approv...
Frequently asked questions
Can I take Dasatinib and Omeprazole together?
No — this combination should generally be avoided. Avoid proton-pump inhibitors during dasatinib therapy. Use an appropriately separated antacid or another oncology-approved strategy.
What is the severity of this interaction?
The interaction between Dasatinib and Omeprazole is classified as Major — avoid combination. Omeprazole persistently raises gastric pH, substantially reducing the pH-dependent dissolution and absorption of dasatinib.
What should I do if I'm prescribed both?
Avoid proton-pump inhibitors during dasatinib therapy. Use an appropriately separated antacid or another oncology-approved strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.