Erlotinib and Omeprazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Erlotinib and Omeprazole unless specifically directed by your doctor.
How Erlotinib interacts with Omeprazole
Omeprazole produces sustained gastric acid suppression, raising gastric pH and substantially reducing the pH-dependent absorption of erlotinib.
What you should do
Avoid proton-pump inhibitors during erlotinib therapy. Use a carefully timed H2-receptor antagonist or antacid only according to oncology guidance.
Key facts
Severity
Major — avoid combination
Mechanism
Omeprazole produces sustained gastric acid suppression, raising gastric pH and substantially reducing the pH-dependent a...
Action
Avoid proton-pump inhibitors during erlotinib therapy. Use a carefully timed H2-receptor antagonist or antacid only acco...
Frequently asked questions
Can I take Erlotinib and Omeprazole together?
No — this combination should generally be avoided. Avoid proton-pump inhibitors during erlotinib therapy. Use a carefully timed H2-receptor antagonist or antacid only according to oncology guidance.
What is the severity of this interaction?
The interaction between Erlotinib and Omeprazole is classified as Major — avoid combination. Omeprazole produces sustained gastric acid suppression, raising gastric pH and substantially reducing the pH-dependent absorption of erlotinib.
What should I do if I'm prescribed both?
Avoid proton-pump inhibitors during erlotinib therapy. Use a carefully timed H2-receptor antagonist or antacid only according to oncology guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.