Diazepam and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Diazepam and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Diazepam interacts with Fluconazole

Fluconazole inhibits CYP2C19 and CYP3A4-mediated diazepam metabolism, increasing and prolonging sedation and psychomotor impairment.

What you should do

Use a lower diazepam dose or a benzodiazepine primarily cleared by glucuronidation, and monitor for excessive sedation and respiratory depression.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C19 and CYP3A4-mediated diazepam metabolism, increasing and prolonging sedation and psychomotor...

Action

Use a lower diazepam dose or a benzodiazepine primarily cleared by glucuronidation, and monitor for excessive sedation a...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diazepam and Fluconazole together?

With caution. Use a lower diazepam dose or a benzodiazepine primarily cleared by glucuronidation, and monitor for excessive sedation and respiratory depression.

What is the severity of this interaction?

The interaction between Diazepam and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP2C19 and CYP3A4-mediated diazepam metabolism, increasing and prolonging sedation and psychomotor impairment.

What should I do if I'm prescribed both?

Use a lower diazepam dose or a benzodiazepine primarily cleared by glucuronidation, and monitor for excessive sedation and respiratory depression. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.