Diazepam and Oxycodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Diazepam and Oxycodone unless specifically directed by your doctor.
How Diazepam interacts with Oxycodone
Additive CNS and respiratory depression via combined GABA-A potentiation and mu-opioid receptor agonism, increasing risk of fatal respiratory depression.
What you should do
Avoid combination where possible. If essential, use the lowest effective doses, limit duration, and counsel patient on overdose signs; consider naloxone co-prescription.
Key facts
Severity
Major — avoid combination
Mechanism
Additive CNS and respiratory depression via combined GABA-A potentiation and mu-opioid receptor agonism, increasing risk...
Action
Avoid combination where possible. If essential, use the lowest effective doses, limit duration, and counsel patient on o...
Frequently asked questions
Can I take Diazepam and Oxycodone together?
No — this combination should generally be avoided. Avoid combination where possible. If essential, use the lowest effective doses, limit duration, and counsel patient on overdose signs; consider naloxone co-prescription.
What is the severity of this interaction?
The interaction between Diazepam and Oxycodone is classified as Major — avoid combination. Additive CNS and respiratory depression via combined GABA-A potentiation and mu-opioid receptor agonism, increasing risk of fatal respiratory depression.
What should I do if I'm prescribed both?
Avoid combination where possible. If essential, use the lowest effective doses, limit duration, and counsel patient on overdose signs; consider naloxone co-prescription. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.