Oxycodone and Pregabalin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Oxycodone and Pregabalin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Oxycodone interacts with Pregabalin

Additive CNS and respiratory depression through gabapentinoid α2δ binding and µ-opioid receptor agonism, increasing risk of fatal respiratory depression.

What you should do

Start at the lowest effective doses, avoid in opioid-naive patients and those with sleep apnoea or COPD, and counsel on overdose risk.

Key facts

Severity

Major — avoid combination

Mechanism

Additive CNS and respiratory depression through gabapentinoid α2δ binding and µ-opioid receptor agonism, increasing risk...

Action

Start at the lowest effective doses, avoid in opioid-naive patients and those with sleep apnoea or COPD, and counsel on ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Oxycodone and Pregabalin together?

No — this combination should generally be avoided. Start at the lowest effective doses, avoid in opioid-naive patients and those with sleep apnoea or COPD, and counsel on overdose risk.

What is the severity of this interaction?

The interaction between Oxycodone and Pregabalin is classified as Major — avoid combination. Additive CNS and respiratory depression through gabapentinoid α2δ binding and µ-opioid receptor agonism, increasing risk of fatal respiratory depression.

What should I do if I'm prescribed both?

Start at the lowest effective doses, avoid in opioid-naive patients and those with sleep apnoea or COPD, and counsel on overdose risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.