Naltrexone and Oxycodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Naltrexone and Oxycodone unless specifically directed by your doctor.
How Naltrexone interacts with Oxycodone
Naltrexone competitively antagonizes opioid receptors, blocking oxycodone analgesic and euphoric effects. Attempts to overcome blockade may lead to delayed opioid toxicity when naltrexone effect wanes.
What you should do
Avoid opioid analgesics in patients taking naltrexone unless managed as an emergency. Use non-opioid analgesia or specialist-supervised pain management.
Key facts
Severity
Major — avoid combination
Mechanism
Naltrexone competitively antagonizes opioid receptors, blocking oxycodone analgesic and euphoric effects. Attempts to ov...
Action
Avoid opioid analgesics in patients taking naltrexone unless managed as an emergency. Use non-opioid analgesia or specia...
Frequently asked questions
Can I take Naltrexone and Oxycodone together?
No — this combination should generally be avoided. Avoid opioid analgesics in patients taking naltrexone unless managed as an emergency. Use non-opioid analgesia or specialist-supervised pain management.
What is the severity of this interaction?
The interaction between Naltrexone and Oxycodone is classified as Major — avoid combination. Naltrexone competitively antagonizes opioid receptors, blocking oxycodone analgesic and euphoric effects. Attempts to overcome blockade may lead to delayed opioid toxicity when naltrexone effect wanes.
What should I do if I'm prescribed both?
Avoid opioid analgesics in patients taking naltrexone unless managed as an emergency. Use non-opioid analgesia or specialist-supervised pain management. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.