Digoxin and Quinidine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Digoxin and Quinidine unless specifically directed by your doctor.
How Digoxin interacts with Quinidine
Quinidine inhibits P-glycoprotein-mediated renal tubular and biliary digoxin elimination, doubling serum digoxin levels within 24-48 hours.
What you should do
Reduce digoxin dose by 50% at initiation of quinidine and monitor serum digoxin levels and ECG for signs of toxicity.
Key facts
Severity
Major — avoid combination
Mechanism
Quinidine inhibits P-glycoprotein-mediated renal tubular and biliary digoxin elimination, doubling serum digoxin levels ...
Action
Reduce digoxin dose by 50% at initiation of quinidine and monitor serum digoxin levels and ECG for signs of toxicity.
Frequently asked questions
Can I take Digoxin and Quinidine together?
No — this combination should generally be avoided. Reduce digoxin dose by 50% at initiation of quinidine and monitor serum digoxin levels and ECG for signs of toxicity.
What is the severity of this interaction?
The interaction between Digoxin and Quinidine is classified as Major — avoid combination. Quinidine inhibits P-glycoprotein-mediated renal tubular and biliary digoxin elimination, doubling serum digoxin levels within 24-48 hours.
What should I do if I'm prescribed both?
Reduce digoxin dose by 50% at initiation of quinidine and monitor serum digoxin levels and ECG for signs of toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.