Quinidine and Verapamil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Quinidine and Verapamil unless specifically directed by your doctor.
How Quinidine interacts with Verapamil
Both drugs depress cardiac conduction, and verapamil can inhibit P-glycoprotein and CYP3A4 pathways affecting quinidine exposure, increasing risk of hypotension, bradycardia, and arrhythmias.
What you should do
Avoid unless specialist-supervised. Use ECG and blood pressure monitoring if combination therapy is necessary.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs depress cardiac conduction, and verapamil can inhibit P-glycoprotein and CYP3A4 pathways affecting quinidine ...
Action
Avoid unless specialist-supervised. Use ECG and blood pressure monitoring if combination therapy is necessary.
Frequently asked questions
Can I take Quinidine and Verapamil together?
No — this combination should generally be avoided. Avoid unless specialist-supervised. Use ECG and blood pressure monitoring if combination therapy is necessary.
What is the severity of this interaction?
The interaction between Quinidine and Verapamil is classified as Major — avoid combination. Both drugs depress cardiac conduction, and verapamil can inhibit P-glycoprotein and CYP3A4 pathways affecting quinidine exposure, increasing risk of hypotension, bradycardia, and arrhythmias.
What should I do if I'm prescribed both?
Avoid unless specialist-supervised. Use ECG and blood pressure monitoring if combination therapy is necessary. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.