Quinidine and Sotalol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Quinidine and Sotalol unless specifically directed by your doctor.
How Quinidine interacts with Sotalol
Both are class III antiarrhythmics (quinidine also class Ia) that prolong the QT interval through potassium channel blockade, causing additive risk of torsades de pointes.
What you should do
Avoid combination. If unavoidable, monitor ECG, correct potassium and magnesium, and discontinue if QTc exceeds 500 ms.
Key facts
Severity
Major — avoid combination
Mechanism
Both are class III antiarrhythmics (quinidine also class Ia) that prolong the QT interval through potassium channel bloc...
Action
Avoid combination. If unavoidable, monitor ECG, correct potassium and magnesium, and discontinue if QTc exceeds 500 ms.
Frequently asked questions
Can I take Quinidine and Sotalol together?
No — this combination should generally be avoided. Avoid combination. If unavoidable, monitor ECG, correct potassium and magnesium, and discontinue if QTc exceeds 500 ms.
What is the severity of this interaction?
The interaction between Quinidine and Sotalol is classified as Major — avoid combination. Both are class III antiarrhythmics (quinidine also class Ia) that prolong the QT interval through potassium channel blockade, causing additive risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid combination. If unavoidable, monitor ECG, correct potassium and magnesium, and discontinue if QTc exceeds 500 ms. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.