Diltiazem and Metoprolol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Diltiazem and Metoprolol unless specifically directed by your doctor.
How Diltiazem interacts with Metoprolol
Both drugs depress sinoatrial and atrioventricular nodal conduction; diltiazem also inhibits CYP2D6 metabolism of metoprolol, raising its plasma levels.
What you should do
Use the combination only when necessary, start with low doses, and monitor for bradycardia, AV block, hypotension and heart failure.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs depress sinoatrial and atrioventricular nodal conduction; diltiazem also inhibits CYP2D6 metabolism of metopr...
Action
Use the combination only when necessary, start with low doses, and monitor for bradycardia, AV block, hypotension and he...
Frequently asked questions
Can I take Diltiazem and Metoprolol together?
No — this combination should generally be avoided. Use the combination only when necessary, start with low doses, and monitor for bradycardia, AV block, hypotension and heart failure.
What is the severity of this interaction?
The interaction between Diltiazem and Metoprolol is classified as Major — avoid combination. Both drugs depress sinoatrial and atrioventricular nodal conduction; diltiazem also inhibits CYP2D6 metabolism of metoprolol, raising its plasma levels.
What should I do if I'm prescribed both?
Use the combination only when necessary, start with low doses, and monitor for bradycardia, AV block, hypotension and heart failure. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.