Diltiazem and Ivabradine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Diltiazem and Ivabradine unless specifically directed by your doctor.

How Diltiazem interacts with Ivabradine

Diltiazem inhibits CYP3A4 metabolism of ivabradine and also slows heart rate independently, producing additive bradycardia.

What you should do

Combination is contraindicated due to risk of severe bradycardia. Use an alternative rate-control or anti-anginal strategy.

Key facts

Severity

Major — avoid combination

Mechanism

Diltiazem inhibits CYP3A4 metabolism of ivabradine and also slows heart rate independently, producing additive bradycard...

Action

Combination is contraindicated due to risk of severe bradycardia. Use an alternative rate-control or anti-anginal strate...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Diltiazem and Ivabradine together?

No — this combination should generally be avoided. Combination is contraindicated due to risk of severe bradycardia. Use an alternative rate-control or anti-anginal strategy.

What is the severity of this interaction?

The interaction between Diltiazem and Ivabradine is classified as Major — avoid combination. Diltiazem inhibits CYP3A4 metabolism of ivabradine and also slows heart rate independently, producing additive bradycardia.

What should I do if I'm prescribed both?

Combination is contraindicated due to risk of severe bradycardia. Use an alternative rate-control or anti-anginal strategy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 15, 2026 by iMedic Medical Editorial Team. Our editorial process.