Colchicine and Diltiazem: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Colchicine and Diltiazem unless specifically directed by your doctor.
How Colchicine interacts with Diltiazem
Diltiazem inhibits both CYP3A4 and P-glycoprotein, the two main elimination pathways of colchicine, raising plasma concentrations and risk of neuromyopathy and bone marrow suppression.
What you should do
Reduce colchicine dose (e.g. halve maintenance dose, do not exceed 0.6 mg/day) and avoid the combination entirely in patients with renal or hepatic impairment.
Key facts
Severity
Major — avoid combination
Mechanism
Diltiazem inhibits both CYP3A4 and P-glycoprotein, the two main elimination pathways of colchicine, raising plasma conce...
Action
Reduce colchicine dose (e.g. halve maintenance dose, do not exceed 0.6 mg/day) and avoid the combination entirely in pat...
Frequently asked questions
Can I take Colchicine and Diltiazem together?
No — this combination should generally be avoided. Reduce colchicine dose (e.g. halve maintenance dose, do not exceed 0.6 mg/day) and avoid the combination entirely in patients with renal or hepatic impairment.
What is the severity of this interaction?
The interaction between Colchicine and Diltiazem is classified as Major — avoid combination. Diltiazem inhibits both CYP3A4 and P-glycoprotein, the two main elimination pathways of colchicine, raising plasma concentrations and risk of neuromyopathy and bone marrow suppression.
What should I do if I'm prescribed both?
Reduce colchicine dose (e.g. halve maintenance dose, do not exceed 0.6 mg/day) and avoid the combination entirely in patients with renal or hepatic impairment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.