Enalapril and Losartan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Enalapril and Losartan unless specifically directed by your doctor.
How Enalapril interacts with Losartan
Both drugs inhibit the renin-angiotensin-aldosterone system, increasing risk of hyperkalemia, hypotension, and acute kidney injury. Dual blockade provides limited additional benefit for most indications.
What you should do
Avoid routine combined use. If a specialist indication exists, monitor potassium, creatinine, blood pressure, and volume status closely.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit the renin-angiotensin-aldosterone system, increasing risk of hyperkalemia, hypotension, and acute kid...
Action
Avoid routine combined use. If a specialist indication exists, monitor potassium, creatinine, blood pressure, and volume...
Frequently asked questions
Can I take Enalapril and Losartan together?
No — this combination should generally be avoided. Avoid routine combined use. If a specialist indication exists, monitor potassium, creatinine, blood pressure, and volume status closely.
What is the severity of this interaction?
The interaction between Enalapril and Losartan is classified as Major — avoid combination. Both drugs inhibit the renin-angiotensin-aldosterone system, increasing risk of hyperkalemia, hypotension, and acute kidney injury. Dual blockade provides limited additional benefit for most indications.
What should I do if I'm prescribed both?
Avoid routine combined use. If a specialist indication exists, monitor potassium, creatinine, blood pressure, and volume status closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.