Lisinopril and Losartan: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Lisinopril and Losartan unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Lisinopril interacts with Losartan

Both drugs block the renin-angiotensin system, increasing risk of hyperkalemia, hypotension, and renal impairment without routine additive benefit. Risk is higher in chronic kidney disease, diabetes, and older adults.

What you should do

Avoid routine dual renin-angiotensin system blockade. If a specialist indication exists, monitor potassium, blood pressure, and renal function closely.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs block the renin-angiotensin system, increasing risk of hyperkalemia, hypotension, and renal impairment withou...

Action

Avoid routine dual renin-angiotensin system blockade. If a specialist indication exists, monitor potassium, blood pressu...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lisinopril and Losartan together?

No — this combination should generally be avoided. Avoid routine dual renin-angiotensin system blockade. If a specialist indication exists, monitor potassium, blood pressure, and renal function closely.

What is the severity of this interaction?

The interaction between Lisinopril and Losartan is classified as Major — avoid combination. Both drugs block the renin-angiotensin system, increasing risk of hyperkalemia, hypotension, and renal impairment without routine additive benefit. Risk is higher in chronic kidney disease, diabetes, and older adults.

What should I do if I'm prescribed both?

Avoid routine dual renin-angiotensin system blockade. If a specialist indication exists, monitor potassium, blood pressure, and renal function closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.