Enalapril and Sacubitril Valsartan: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Enalapril and Sacubitril Valsartan unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Enalapril interacts with Sacubitril Valsartan

Concurrent ACE inhibitor and neprilysin inhibitor use causes additive bradykinin accumulation, substantially increasing risk of angioedema.

What you should do

Contraindicated. Allow a 36-hour washout between discontinuing the ACE inhibitor and starting sacubitril/valsartan.

Key facts

Severity

Major — avoid combination

Mechanism

Concurrent ACE inhibitor and neprilysin inhibitor use causes additive bradykinin accumulation, substantially increasing ...

Action

Contraindicated. Allow a 36-hour washout between discontinuing the ACE inhibitor and starting sacubitril/valsartan.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Enalapril and Sacubitril Valsartan together?

No — this combination should generally be avoided. Contraindicated. Allow a 36-hour washout between discontinuing the ACE inhibitor and starting sacubitril/valsartan.

What is the severity of this interaction?

The interaction between Enalapril and Sacubitril Valsartan is classified as Major — avoid combination. Concurrent ACE inhibitor and neprilysin inhibitor use causes additive bradykinin accumulation, substantially increasing risk of angioedema.

What should I do if I'm prescribed both?

Contraindicated. Allow a 36-hour washout between discontinuing the ACE inhibitor and starting sacubitril/valsartan. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.