Erythromycin and Rivaroxaban: Drug Interaction Guide
Quick answer: This combination requires caution. Erythromycin and Rivaroxaban can be used together with adjustments and monitoring.
How Erythromycin interacts with Rivaroxaban
Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing rivaroxaban exposure by approximately 30-40% and bleeding risk.
What you should do
Use with caution, particularly in patients with renal impairment; consider an alternative antibiotic or watch closely for bleeding.
Key facts
Severity
Moderate — caution required
Mechanism
Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing rivaroxaban exposure by approximately 30-40% and bleeding ri...
Action
Use with caution, particularly in patients with renal impairment; consider an alternative antibiotic or watch closely fo...
Frequently asked questions
Can I take Erythromycin and Rivaroxaban together?
With caution. Use with caution, particularly in patients with renal impairment; consider an alternative antibiotic or watch closely for bleeding.
What is the severity of this interaction?
The interaction between Erythromycin and Rivaroxaban is classified as Moderate — caution required. Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing rivaroxaban exposure by approximately 30-40% and bleeding risk.
What should I do if I'm prescribed both?
Use with caution, particularly in patients with renal impairment; consider an alternative antibiotic or watch closely for bleeding. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.