Erythromycin and Sildenafil: Drug Interaction Guide
Quick answer: This combination requires caution. Erythromycin and Sildenafil can be used together with adjustments and monitoring.
How Erythromycin interacts with Sildenafil
Erythromycin inhibits CYP3A4-mediated metabolism of sildenafil, approximately doubling sildenafil AUC and prolonging hypotensive and visual side effects.
What you should do
Reduce sildenafil starting dose to 25 mg when used with erythromycin or other moderate CYP3A4 inhibitors. Counsel patient regarding hypotension and priapism risk.
Key facts
Severity
Moderate — caution required
Mechanism
Erythromycin inhibits CYP3A4-mediated metabolism of sildenafil, approximately doubling sildenafil AUC and prolonging hyp...
Action
Reduce sildenafil starting dose to 25 mg when used with erythromycin or other moderate CYP3A4 inhibitors. Counsel patien...
Frequently asked questions
Can I take Erythromycin and Sildenafil together?
With caution. Reduce sildenafil starting dose to 25 mg when used with erythromycin or other moderate CYP3A4 inhibitors. Counsel patient regarding hypotension and priapism risk.
What is the severity of this interaction?
The interaction between Erythromycin and Sildenafil is classified as Moderate — caution required. Erythromycin inhibits CYP3A4-mediated metabolism of sildenafil, approximately doubling sildenafil AUC and prolonging hypotensive and visual side effects.
What should I do if I'm prescribed both?
Reduce sildenafil starting dose to 25 mg when used with erythromycin or other moderate CYP3A4 inhibitors. Counsel patient regarding hypotension and priapism risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.