Erythromycin and Sotalol: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Erythromycin and Sotalol unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Erythromycin interacts with Sotalol

Both agents block the cardiac IKr potassium channel, with additive QT-interval prolongation and risk of torsades de pointes.

What you should do

Avoid combination. If erythromycin is essential, hospitalise for cardiac monitoring, correct electrolytes and consider holding sotalol.

Key facts

Severity

Major — avoid combination

Mechanism

Both agents block the cardiac IKr potassium channel, with additive QT-interval prolongation and risk of torsades de poin...

Action

Avoid combination. If erythromycin is essential, hospitalise for cardiac monitoring, correct electrolytes and consider h...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Erythromycin and Sotalol together?

No — this combination should generally be avoided. Avoid combination. If erythromycin is essential, hospitalise for cardiac monitoring, correct electrolytes and consider holding sotalol.

What is the severity of this interaction?

The interaction between Erythromycin and Sotalol is classified as Major — avoid combination. Both agents block the cardiac IKr potassium channel, with additive QT-interval prolongation and risk of torsades de pointes.

What should I do if I'm prescribed both?

Avoid combination. If erythromycin is essential, hospitalise for cardiac monitoring, correct electrolytes and consider holding sotalol. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.