Escitalopram and Fluconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Escitalopram and Fluconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Escitalopram interacts with Fluconazole

Fluconazole inhibits CYP2C19, increasing escitalopram exposure. Both agents can also contribute to QT interval prolongation.

What you should do

Use the lowest effective escitalopram dose and consider ECG monitoring in patients with QT risk factors. Consider an alternative antifungal if risk is high.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C19, increasing escitalopram exposure. Both agents can also contribute to QT interval prolongat...

Action

Use the lowest effective escitalopram dose and consider ECG monitoring in patients with QT risk factors. Consider an alt...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Escitalopram and Fluconazole together?

With caution. Use the lowest effective escitalopram dose and consider ECG monitoring in patients with QT risk factors. Consider an alternative antifungal if risk is high.

What is the severity of this interaction?

The interaction between Escitalopram and Fluconazole is classified as Moderate — caution required. Fluconazole inhibits CYP2C19, increasing escitalopram exposure. Both agents can also contribute to QT interval prolongation.

What should I do if I'm prescribed both?

Use the lowest effective escitalopram dose and consider ECG monitoring in patients with QT risk factors. Consider an alternative antifungal if risk is high. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.