Ethinyl Estradiol and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ethinyl Estradiol and Rifampicin unless specifically directed by your doctor.
How Ethinyl Estradiol interacts with Rifampicin
Rifampicin strongly induces CYP3A4 and glucuronidation pathways, increasing metabolism of ethinyl estradiol. This can reduce contraceptive efficacy and cause breakthrough bleeding.
What you should do
Use a non-hormonal or reliably unaffected contraceptive method during rifampicin therapy and for the recommended period after stopping.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4 and glucuronidation pathways, increasing metabolism of ethinyl estradiol. This can re...
Action
Use a non-hormonal or reliably unaffected contraceptive method during rifampicin therapy and for the recommended period ...
Frequently asked questions
Can I take Ethinyl Estradiol and Rifampicin together?
No — this combination should generally be avoided. Use a non-hormonal or reliably unaffected contraceptive method during rifampicin therapy and for the recommended period after stopping.
What is the severity of this interaction?
The interaction between Ethinyl Estradiol and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and glucuronidation pathways, increasing metabolism of ethinyl estradiol. This can reduce contraceptive efficacy and cause breakthrough bleeding.
What should I do if I'm prescribed both?
Use a non-hormonal or reliably unaffected contraceptive method during rifampicin therapy and for the recommended period after stopping. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.