Ethinylestradiol Levonorgestrel and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ethinylestradiol Levonorgestrel and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ethinylestradiol Levonorgestrel interacts with Rifampicin

Rifampicin strongly induces CYP3A4, uridine diphosphate-glucuronosyltransferases, and drug transporters, accelerating clearance of both contraceptive hormones. Hormone exposure can fall below that required for reliable contraception.

What you should do

Do not rely on the combined hormonal contraceptive during rifampicin treatment. Use an effective nonhormonal or unaffected contraceptive method during therapy and for the recommended period after rifampicin is stopped.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin strongly induces CYP3A4, uridine diphosphate-glucuronosyltransferases, and drug transporters, accelerating cl...

Action

Do not rely on the combined hormonal contraceptive during rifampicin treatment. Use an effective nonhormonal or unaffect...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ethinylestradiol Levonorgestrel and Rifampicin together?

No — this combination should generally be avoided. Do not rely on the combined hormonal contraceptive during rifampicin treatment. Use an effective nonhormonal or unaffected contraceptive method during therapy and for the recommended period after rifampicin is stopped.

What is the severity of this interaction?

The interaction between Ethinylestradiol Levonorgestrel and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4, uridine diphosphate-glucuronosyltransferases, and drug transporters, accelerating clearance of both contraceptive hormones. Hormone exposure can fall below that required for reliable contraception.

What should I do if I'm prescribed both?

Do not rely on the combined hormonal contraceptive during rifampicin treatment. Use an effective nonhormonal or unaffected contraceptive method during therapy and for the recommended period after rifampicin is stopped. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.