Ethinylestradiol and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ethinylestradiol and Rifampicin unless specifically directed by your doctor.
How Ethinylestradiol interacts with Rifampicin
Rifampicin induces CYP3A4 and SULT enzymes, accelerating metabolism of both ethinylestradiol and progestogen and reducing combined oral contraceptive efficacy.
What you should do
Use a non-hormonal contraceptive method during rifampicin treatment and for 4 weeks after discontinuation; depot medroxyprogesterone or copper IUD are suitable.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin induces CYP3A4 and SULT enzymes, accelerating metabolism of both ethinylestradiol and progestogen and reducin...
Action
Use a non-hormonal contraceptive method during rifampicin treatment and for 4 weeks after discontinuation; depot medroxy...
Frequently asked questions
Can I take Ethinylestradiol and Rifampicin together?
No — this combination should generally be avoided. Use a non-hormonal contraceptive method during rifampicin treatment and for 4 weeks after discontinuation; depot medroxyprogesterone or copper IUD are suitable.
What is the severity of this interaction?
The interaction between Ethinylestradiol and Rifampicin is classified as Major — avoid combination. Rifampicin induces CYP3A4 and SULT enzymes, accelerating metabolism of both ethinylestradiol and progestogen and reducing combined oral contraceptive efficacy.
What should I do if I'm prescribed both?
Use a non-hormonal contraceptive method during rifampicin treatment and for 4 weeks after discontinuation; depot medroxyprogesterone or copper IUD are suitable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.