Everolimus and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Everolimus and Rifampicin unless specifically directed by your doctor.
How Everolimus interacts with Rifampicin
Rifampicin induces CYP3A4 and P-glycoprotein, decreasing everolimus AUC by up to 60% and risking subtherapeutic immunosuppression or oncologic response.
What you should do
Avoid concurrent use; if essential, double the everolimus dose with frequent therapeutic drug monitoring and re-adjust on rifampicin discontinuation.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin induces CYP3A4 and P-glycoprotein, decreasing everolimus AUC by up to 60% and risking subtherapeutic immunosu...
Action
Avoid concurrent use; if essential, double the everolimus dose with frequent therapeutic drug monitoring and re-adjust o...
Frequently asked questions
Can I take Everolimus and Rifampicin together?
No — this combination should generally be avoided. Avoid concurrent use; if essential, double the everolimus dose with frequent therapeutic drug monitoring and re-adjust on rifampicin discontinuation.
What is the severity of this interaction?
The interaction between Everolimus and Rifampicin is classified as Major — avoid combination. Rifampicin induces CYP3A4 and P-glycoprotein, decreasing everolimus AUC by up to 60% and risking subtherapeutic immunosuppression or oncologic response.
What should I do if I'm prescribed both?
Avoid concurrent use; if essential, double the everolimus dose with frequent therapeutic drug monitoring and re-adjust on rifampicin discontinuation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.