Fluconazole and Gliclazide: Drug Interaction Guide

Quick answer: This combination requires caution. Fluconazole and Gliclazide can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Fluconazole interacts with Gliclazide

Fluconazole inhibits CYP2C9, reducing metabolism of sulfonylureas such as gliclazide. This can increase insulin release and cause hypoglycemia.

What you should do

Monitor blood glucose more frequently and consider temporary sulfonylurea dose reduction. Counsel patients on hypoglycemia recognition and treatment.

Key facts

Severity

Moderate — caution required

Mechanism

Fluconazole inhibits CYP2C9, reducing metabolism of sulfonylureas such as gliclazide. This can increase insulin release ...

Action

Monitor blood glucose more frequently and consider temporary sulfonylurea dose reduction. Counsel patients on hypoglycem...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Fluconazole and Gliclazide together?

With caution. Monitor blood glucose more frequently and consider temporary sulfonylurea dose reduction. Counsel patients on hypoglycemia recognition and treatment.

What is the severity of this interaction?

The interaction between Fluconazole and Gliclazide is classified as Moderate — caution required. Fluconazole inhibits CYP2C9, reducing metabolism of sulfonylureas such as gliclazide. This can increase insulin release and cause hypoglycemia.

What should I do if I'm prescribed both?

Monitor blood glucose more frequently and consider temporary sulfonylurea dose reduction. Counsel patients on hypoglycemia recognition and treatment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.