Fluconazole and Sotalol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluconazole and Sotalol unless specifically directed by your doctor.
How Fluconazole interacts with Sotalol
Both fluconazole and sotalol can inhibit cardiac repolarizing potassium currents and prolong the QT interval, increasing torsades de pointes risk.
What you should do
Avoid concurrent use, particularly in patients with renal impairment, bradycardia, or electrolyte abnormalities. Choose an antifungal without clinically relevant QT effects.
Key facts
Severity
Major — avoid combination
Mechanism
Both fluconazole and sotalol can inhibit cardiac repolarizing potassium currents and prolong the QT interval, increasing...
Action
Avoid concurrent use, particularly in patients with renal impairment, bradycardia, or electrolyte abnormalities. Choose ...
Frequently asked questions
Can I take Fluconazole and Sotalol together?
No — this combination should generally be avoided. Avoid concurrent use, particularly in patients with renal impairment, bradycardia, or electrolyte abnormalities. Choose an antifungal without clinically relevant QT effects.
What is the severity of this interaction?
The interaction between Fluconazole and Sotalol is classified as Major — avoid combination. Both fluconazole and sotalol can inhibit cardiac repolarizing potassium currents and prolong the QT interval, increasing torsades de pointes risk.
What should I do if I'm prescribed both?
Avoid concurrent use, particularly in patients with renal impairment, bradycardia, or electrolyte abnormalities. Choose an antifungal without clinically relevant QT effects. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.