Heparin and Ketorolac: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Heparin and Ketorolac unless specifically directed by your doctor.

How Heparin interacts with Ketorolac

Combination of anticoagulant and NSAID effects on platelet aggregation and gastric mucosa markedly increases the risk of major bleeding, particularly GI haemorrhage.

What you should do

Avoid combination; use paracetamol or opioid analgesia in anticoagulated patients requiring pain relief.

Key facts

Severity

Major — avoid combination

Mechanism

Combination of anticoagulant and NSAID effects on platelet aggregation and gastric mucosa markedly increases the risk of...

Action

Avoid combination; use paracetamol or opioid analgesia in anticoagulated patients requiring pain relief.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Heparin and Ketorolac together?

No — this combination should generally be avoided. Avoid combination; use paracetamol or opioid analgesia in anticoagulated patients requiring pain relief.

What is the severity of this interaction?

The interaction between Heparin and Ketorolac is classified as Major — avoid combination. Combination of anticoagulant and NSAID effects on platelet aggregation and gastric mucosa markedly increases the risk of major bleeding, particularly GI haemorrhage.

What should I do if I'm prescribed both?

Avoid combination; use paracetamol or opioid analgesia in anticoagulated patients requiring pain relief. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 16, 2026 by iMedic Medical Editorial Team. Our editorial process.