Ibrutinib and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ibrutinib and Rifampicin unless specifically directed by your doctor.
How Ibrutinib interacts with Rifampicin
Rifampicin strongly induces CYP3A4, markedly accelerating ibrutinib metabolism and reducing antineoplastic exposure.
What you should do
Avoid concomitant use because loss of ibrutinib efficacy is likely. Select a non-inducing alternative to rifampicin whenever possible.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4, markedly accelerating ibrutinib metabolism and reducing antineoplastic exposure.
Action
Avoid concomitant use because loss of ibrutinib efficacy is likely. Select a non-inducing alternative to rifampicin when...
Frequently asked questions
Can I take Ibrutinib and Rifampicin together?
No — this combination should generally be avoided. Avoid concomitant use because loss of ibrutinib efficacy is likely. Select a non-inducing alternative to rifampicin whenever possible.
What is the severity of this interaction?
The interaction between Ibrutinib and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4, markedly accelerating ibrutinib metabolism and reducing antineoplastic exposure.
What should I do if I'm prescribed both?
Avoid concomitant use because loss of ibrutinib efficacy is likely. Select a non-inducing alternative to rifampicin whenever possible. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.