Indinavir and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Indinavir and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Indinavir interacts with Rifampicin

Rifampicin is a potent inducer of CYP3A4, reducing indinavir plasma concentrations by approximately 90% and risking loss of virological control and resistance.

What you should do

Combination is contraindicated. Substitute rifampicin with rifabutin at reduced dose, or change the antiretroviral regimen.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin is a potent inducer of CYP3A4, reducing indinavir plasma concentrations by approximately 90% and risking loss...

Action

Combination is contraindicated. Substitute rifampicin with rifabutin at reduced dose, or change the antiretroviral regim...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Indinavir and Rifampicin together?

No — this combination should generally be avoided. Combination is contraindicated. Substitute rifampicin with rifabutin at reduced dose, or change the antiretroviral regimen.

What is the severity of this interaction?

The interaction between Indinavir and Rifampicin is classified as Major — avoid combination. Rifampicin is a potent inducer of CYP3A4, reducing indinavir plasma concentrations by approximately 90% and risking loss of virological control and resistance.

What should I do if I'm prescribed both?

Combination is contraindicated. Substitute rifampicin with rifabutin at reduced dose, or change the antiretroviral regimen. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.