Irinotecan and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Irinotecan and Rifampicin unless specifically directed by your doctor.
How Irinotecan interacts with Rifampicin
Rifampicin induces CYP3A4 and UGT1A1, reducing exposure to irinotecan and its active metabolite SN-38, compromising antitumor efficacy.
What you should do
Avoid rifampicin during irinotecan therapy; if rifampicin is required for tuberculosis, consider alternative chemotherapy or specialist oncology review.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin induces CYP3A4 and UGT1A1, reducing exposure to irinotecan and its active metabolite SN-38, compromising anti...
Action
Avoid rifampicin during irinotecan therapy; if rifampicin is required for tuberculosis, consider alternative chemotherap...
Frequently asked questions
Can I take Irinotecan and Rifampicin together?
No — this combination should generally be avoided. Avoid rifampicin during irinotecan therapy; if rifampicin is required for tuberculosis, consider alternative chemotherapy or specialist oncology review.
What is the severity of this interaction?
The interaction between Irinotecan and Rifampicin is classified as Major — avoid combination. Rifampicin induces CYP3A4 and UGT1A1, reducing exposure to irinotecan and its active metabolite SN-38, compromising antitumor efficacy.
What should I do if I'm prescribed both?
Avoid rifampicin during irinotecan therapy; if rifampicin is required for tuberculosis, consider alternative chemotherapy or specialist oncology review. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.