Itraconazole and Ivabradine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Ivabradine unless specifically directed by your doctor.
How Itraconazole interacts with Ivabradine
Itraconazole is a strong CYP3A4 inhibitor and ivabradine is primarily metabolized by CYP3A4. Increased ivabradine exposure can cause excessive bradycardia and conduction disturbances.
What you should do
Avoid coadministration. Select a different antifungal or pause ivabradine under specialist guidance.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole is a strong CYP3A4 inhibitor and ivabradine is primarily metabolized by CYP3A4. Increased ivabradine exposu...
Action
Avoid coadministration. Select a different antifungal or pause ivabradine under specialist guidance.
Frequently asked questions
Can I take Itraconazole and Ivabradine together?
No — this combination should generally be avoided. Avoid coadministration. Select a different antifungal or pause ivabradine under specialist guidance.
What is the severity of this interaction?
The interaction between Itraconazole and Ivabradine is classified as Major — avoid combination. Itraconazole is a strong CYP3A4 inhibitor and ivabradine is primarily metabolized by CYP3A4. Increased ivabradine exposure can cause excessive bradycardia and conduction disturbances.
What should I do if I'm prescribed both?
Avoid coadministration. Select a different antifungal or pause ivabradine under specialist guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.