Ivabradine and Verapamil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ivabradine and Verapamil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ivabradine interacts with Verapamil

Verapamil inhibits CYP3A4 (increasing ivabradine exposure) and independently slows the SA node, producing excessive bradycardia and conduction block.

What you should do

Combination is contraindicated. Use a non-rate-limiting calcium-channel blocker (amlodipine) if needed.

Key facts

Severity

Major — avoid combination

Mechanism

Verapamil inhibits CYP3A4 (increasing ivabradine exposure) and independently slows the SA node, producing excessive brad...

Action

Combination is contraindicated. Use a non-rate-limiting calcium-channel blocker (amlodipine) if needed.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ivabradine and Verapamil together?

No — this combination should generally be avoided. Combination is contraindicated. Use a non-rate-limiting calcium-channel blocker (amlodipine) if needed.

What is the severity of this interaction?

The interaction between Ivabradine and Verapamil is classified as Major — avoid combination. Verapamil inhibits CYP3A4 (increasing ivabradine exposure) and independently slows the SA node, producing excessive bradycardia and conduction block.

What should I do if I'm prescribed both?

Combination is contraindicated. Use a non-rate-limiting calcium-channel blocker (amlodipine) if needed. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.