Itraconazole and Methadone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Methadone unless specifically directed by your doctor.
How Itraconazole interacts with Methadone
Itraconazole inhibits CYP3A4 metabolism of methadone and both drugs prolong the QT interval, increasing risk of methadone toxicity and torsades de pointes.
What you should do
Obtain ECG before starting, reduce methadone dose, and monitor for sedation, respiratory depression, and QT prolongation.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole inhibits CYP3A4 metabolism of methadone and both drugs prolong the QT interval, increasing risk of methadon...
Action
Obtain ECG before starting, reduce methadone dose, and monitor for sedation, respiratory depression, and QT prolongation...
Frequently asked questions
Can I take Itraconazole and Methadone together?
No — this combination should generally be avoided. Obtain ECG before starting, reduce methadone dose, and monitor for sedation, respiratory depression, and QT prolongation.
What is the severity of this interaction?
The interaction between Itraconazole and Methadone is classified as Major — avoid combination. Itraconazole inhibits CYP3A4 metabolism of methadone and both drugs prolong the QT interval, increasing risk of methadone toxicity and torsades de pointes.
What should I do if I'm prescribed both?
Obtain ECG before starting, reduce methadone dose, and monitor for sedation, respiratory depression, and QT prolongation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.