Ketoconazole and Pimozide: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ketoconazole and Pimozide unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ketoconazole interacts with Pimozide

Ketoconazole strongly inhibits CYP3A4 metabolism of pimozide, increasing plasma levels and risk of QT prolongation, torsades de pointes, and sudden cardiac death.

What you should do

Combination is contraindicated. Avoid all azole antifungals and macrolide antibiotics in patients on pimozide.

Key facts

Severity

Major — avoid combination

Mechanism

Ketoconazole strongly inhibits CYP3A4 metabolism of pimozide, increasing plasma levels and risk of QT prolongation, tors...

Action

Combination is contraindicated. Avoid all azole antifungals and macrolide antibiotics in patients on pimozide.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ketoconazole and Pimozide together?

No — this combination should generally be avoided. Combination is contraindicated. Avoid all azole antifungals and macrolide antibiotics in patients on pimozide.

What is the severity of this interaction?

The interaction between Ketoconazole and Pimozide is classified as Major — avoid combination. Ketoconazole strongly inhibits CYP3A4 metabolism of pimozide, increasing plasma levels and risk of QT prolongation, torsades de pointes, and sudden cardiac death.

What should I do if I'm prescribed both?

Combination is contraindicated. Avoid all azole antifungals and macrolide antibiotics in patients on pimozide. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.