Pimozide and Sertraline: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Pimozide and Sertraline unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Pimozide interacts with Sertraline

Sertraline can increase pimozide exposure and both drugs may prolong the QT interval. This raises the risk of torsades de pointes.

What you should do

Avoid co-prescribing. Choose an alternative antipsychotic or antidepressant with lower QT interaction risk.

Key facts

Severity

Major — avoid combination

Mechanism

Sertraline can increase pimozide exposure and both drugs may prolong the QT interval. This raises the risk of torsades d...

Action

Avoid co-prescribing. Choose an alternative antipsychotic or antidepressant with lower QT interaction risk.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Pimozide and Sertraline together?

No — this combination should generally be avoided. Avoid co-prescribing. Choose an alternative antipsychotic or antidepressant with lower QT interaction risk.

What is the severity of this interaction?

The interaction between Pimozide and Sertraline is classified as Major — avoid combination. Sertraline can increase pimozide exposure and both drugs may prolong the QT interval. This raises the risk of torsades de pointes.

What should I do if I'm prescribed both?

Avoid co-prescribing. Choose an alternative antipsychotic or antidepressant with lower QT interaction risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.