Pimozide and Voriconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Pimozide and Voriconazole unless specifically directed by your doctor.
How Pimozide interacts with Voriconazole
Voriconazole inhibits CYP3A4, reducing pimozide metabolism. Increased pimozide exposure can cause clinically significant QT prolongation and torsades de pointes.
What you should do
Do not coadminister. Choose an alternative antipsychotic or antifungal with lower QT and CYP3A4 interaction risk.
Key facts
Severity
Major — avoid combination
Mechanism
Voriconazole inhibits CYP3A4, reducing pimozide metabolism. Increased pimozide exposure can cause clinically significant...
Action
Do not coadminister. Choose an alternative antipsychotic or antifungal with lower QT and CYP3A4 interaction risk.
Frequently asked questions
Can I take Pimozide and Voriconazole together?
No — this combination should generally be avoided. Do not coadminister. Choose an alternative antipsychotic or antifungal with lower QT and CYP3A4 interaction risk.
What is the severity of this interaction?
The interaction between Pimozide and Voriconazole is classified as Major — avoid combination. Voriconazole inhibits CYP3A4, reducing pimozide metabolism. Increased pimozide exposure can cause clinically significant QT prolongation and torsades de pointes.
What should I do if I'm prescribed both?
Do not coadminister. Choose an alternative antipsychotic or antifungal with lower QT and CYP3A4 interaction risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.