Ledipasvir and Rosuvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ledipasvir and Rosuvastatin unless specifically directed by your doctor.
How Ledipasvir interacts with Rosuvastatin
Ledipasvir inhibits OATP1B1 and BCRP transporters that mediate rosuvastatin hepatic uptake and intestinal efflux, increasing rosuvastatin exposure 5-fold and myopathy risk.
What you should do
Limit rosuvastatin to 10 mg daily during ledipasvir therapy or switch to pravastatin temporarily.
Key facts
Severity
Major — avoid combination
Mechanism
Ledipasvir inhibits OATP1B1 and BCRP transporters that mediate rosuvastatin hepatic uptake and intestinal efflux, increa...
Action
Limit rosuvastatin to 10 mg daily during ledipasvir therapy or switch to pravastatin temporarily.
Frequently asked questions
Can I take Ledipasvir and Rosuvastatin together?
No — this combination should generally be avoided. Limit rosuvastatin to 10 mg daily during ledipasvir therapy or switch to pravastatin temporarily.
What is the severity of this interaction?
The interaction between Ledipasvir and Rosuvastatin is classified as Major — avoid combination. Ledipasvir inhibits OATP1B1 and BCRP transporters that mediate rosuvastatin hepatic uptake and intestinal efflux, increasing rosuvastatin exposure 5-fold and myopathy risk.
What should I do if I'm prescribed both?
Limit rosuvastatin to 10 mg daily during ledipasvir therapy or switch to pravastatin temporarily. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.