Gemfibrozil and Rosuvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Gemfibrozil and Rosuvastatin unless specifically directed by your doctor.
How Gemfibrozil interacts with Rosuvastatin
Gemfibrozil and its glucuronide inhibit OATP1B1-mediated hepatic uptake of rosuvastatin, raising plasma exposure and the risk of myopathy and rhabdomyolysis.
What you should do
Avoid the combination; if a fibrate is required with rosuvastatin, use fenofibrate instead and limit rosuvastatin to a low dose with CK monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Gemfibrozil and its glucuronide inhibit OATP1B1-mediated hepatic uptake of rosuvastatin, raising plasma exposure and the...
Action
Avoid the combination; if a fibrate is required with rosuvastatin, use fenofibrate instead and limit rosuvastatin to a l...
Frequently asked questions
Can I take Gemfibrozil and Rosuvastatin together?
No — this combination should generally be avoided. Avoid the combination; if a fibrate is required with rosuvastatin, use fenofibrate instead and limit rosuvastatin to a low dose with CK monitoring.
What is the severity of this interaction?
The interaction between Gemfibrozil and Rosuvastatin is classified as Major — avoid combination. Gemfibrozil and its glucuronide inhibit OATP1B1-mediated hepatic uptake of rosuvastatin, raising plasma exposure and the risk of myopathy and rhabdomyolysis.
What should I do if I'm prescribed both?
Avoid the combination; if a fibrate is required with rosuvastatin, use fenofibrate instead and limit rosuvastatin to a low dose with CK monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.