Ciclosporin and Rosuvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciclosporin and Rosuvastatin unless specifically directed by your doctor.
How Ciclosporin interacts with Rosuvastatin
Ciclosporin inhibits OATP1B1 and BCRP transporters, dramatically increasing rosuvastatin plasma concentrations and myopathy risk.
What you should do
Avoid combination. If a statin is required in transplant patients, use pravastatin or fluvastatin at low dose with creatine kinase monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Ciclosporin inhibits OATP1B1 and BCRP transporters, dramatically increasing rosuvastatin plasma concentrations and myopa...
Action
Avoid combination. If a statin is required in transplant patients, use pravastatin or fluvastatin at low dose with creat...
Frequently asked questions
Can I take Ciclosporin and Rosuvastatin together?
No — this combination should generally be avoided. Avoid combination. If a statin is required in transplant patients, use pravastatin or fluvastatin at low dose with creatine kinase monitoring.
What is the severity of this interaction?
The interaction between Ciclosporin and Rosuvastatin is classified as Major — avoid combination. Ciclosporin inhibits OATP1B1 and BCRP transporters, dramatically increasing rosuvastatin plasma concentrations and myopathy risk.
What should I do if I'm prescribed both?
Avoid combination. If a statin is required in transplant patients, use pravastatin or fluvastatin at low dose with creatine kinase monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.