Lithium and Nsaid: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Lithium and Nsaid unless specifically directed by your doctor.
How Lithium interacts with Nsaid
NSAIDs reduce renal prostaglandin synthesis, decreasing lithium clearance and raising serum lithium levels, potentially causing toxicity.
What you should do
Avoid chronic NSAID use with lithium. If necessary, monitor lithium levels within 5-7 days of starting NSAID and adjust dose.
Key facts
Severity
Major — avoid combination
Mechanism
NSAIDs reduce renal prostaglandin synthesis, decreasing lithium clearance and raising serum lithium levels, potentially ...
Action
Avoid chronic NSAID use with lithium. If necessary, monitor lithium levels within 5-7 days of starting NSAID and adjust ...
Frequently asked questions
Can I take Lithium and Nsaid together?
No — this combination should generally be avoided. Avoid chronic NSAID use with lithium. If necessary, monitor lithium levels within 5-7 days of starting NSAID and adjust dose.
What is the severity of this interaction?
The interaction between Lithium and Nsaid is classified as Major — avoid combination. NSAIDs reduce renal prostaglandin synthesis, decreasing lithium clearance and raising serum lithium levels, potentially causing toxicity.
What should I do if I'm prescribed both?
Avoid chronic NSAID use with lithium. If necessary, monitor lithium levels within 5-7 days of starting NSAID and adjust dose. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.