Omeprazole and Voriconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Omeprazole and Voriconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Omeprazole interacts with Voriconazole

Voriconazole inhibits CYP2C19 and CYP3A4 metabolism of omeprazole, doubling omeprazole exposure; conversely omeprazole modestly raises voriconazole levels.

What you should do

Halve the omeprazole dose when high-dose voriconazole is used and monitor for voriconazole toxicity (visual disturbance, hepatotoxicity).

Key facts

Severity

Moderate — caution required

Mechanism

Voriconazole inhibits CYP2C19 and CYP3A4 metabolism of omeprazole, doubling omeprazole exposure; conversely omeprazole m...

Action

Halve the omeprazole dose when high-dose voriconazole is used and monitor for voriconazole toxicity (visual disturbance,...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Omeprazole and Voriconazole together?

With caution. Halve the omeprazole dose when high-dose voriconazole is used and monitor for voriconazole toxicity (visual disturbance, hepatotoxicity).

What is the severity of this interaction?

The interaction between Omeprazole and Voriconazole is classified as Moderate — caution required. Voriconazole inhibits CYP2C19 and CYP3A4 metabolism of omeprazole, doubling omeprazole exposure; conversely omeprazole modestly raises voriconazole levels.

What should I do if I'm prescribed both?

Halve the omeprazole dose when high-dose voriconazole is used and monitor for voriconazole toxicity (visual disturbance, hepatotoxicity). Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.