Nelfinavir and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nelfinavir and Rifampicin unless specifically directed by your doctor.
How Nelfinavir interacts with Rifampicin
Rifampicin strongly induces CYP3A4 and drug transporters, markedly reducing nelfinavir exposure. This can lead to virologic failure and resistance.
What you should do
Avoid co-administration. Use an alternative tuberculosis regimen or antiretroviral regimen guided by HIV and infectious disease specialists.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4 and drug transporters, markedly reducing nelfinavir exposure. This can lead to virolo...
Action
Avoid co-administration. Use an alternative tuberculosis regimen or antiretroviral regimen guided by HIV and infectious ...
Frequently asked questions
Can I take Nelfinavir and Rifampicin together?
No — this combination should generally be avoided. Avoid co-administration. Use an alternative tuberculosis regimen or antiretroviral regimen guided by HIV and infectious disease specialists.
What is the severity of this interaction?
The interaction between Nelfinavir and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and drug transporters, markedly reducing nelfinavir exposure. This can lead to virologic failure and resistance.
What should I do if I'm prescribed both?
Avoid co-administration. Use an alternative tuberculosis regimen or antiretroviral regimen guided by HIV and infectious disease specialists. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.