Nifedipine and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nifedipine and Rifampicin unless specifically directed by your doctor.
How Nifedipine interacts with Rifampicin
Rifampicin strongly induces CYP3A4, reducing nifedipine AUC by up to 90% and abolishing its antihypertensive and antianginal effects.
What you should do
Avoid combination. Use an alternative antihypertensive less affected by enzyme induction (e.g., atenolol, hydrochlorothiazide) during rifampicin therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4, reducing nifedipine AUC by up to 90% and abolishing its antihypertensive and antiang...
Action
Avoid combination. Use an alternative antihypertensive less affected by enzyme induction (e.g., atenolol, hydrochlorothi...
Frequently asked questions
Can I take Nifedipine and Rifampicin together?
No — this combination should generally be avoided. Avoid combination. Use an alternative antihypertensive less affected by enzyme induction (e.g., atenolol, hydrochlorothiazide) during rifampicin therapy.
What is the severity of this interaction?
The interaction between Nifedipine and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4, reducing nifedipine AUC by up to 90% and abolishing its antihypertensive and antianginal effects.
What should I do if I'm prescribed both?
Avoid combination. Use an alternative antihypertensive less affected by enzyme induction (e.g., atenolol, hydrochlorothiazide) during rifampicin therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.