Nitrate and Sildenafil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Nitrate and Sildenafil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Nitrate interacts with Sildenafil

Both drugs increase cGMP (sildenafil via PDE5 inhibition, nitrates via NO donation), producing profound vasodilation and potentially fatal hypotension.

What you should do

Combination is absolutely contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administering any nitrate.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs increase cGMP (sildenafil via PDE5 inhibition, nitrates via NO donation), producing profound vasodilation and...

Action

Combination is absolutely contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before admin...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitrate and Sildenafil together?

No — this combination should generally be avoided. Combination is absolutely contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administering any nitrate.

What is the severity of this interaction?

The interaction between Nitrate and Sildenafil is classified as Major — avoid combination. Both drugs increase cGMP (sildenafil via PDE5 inhibition, nitrates via NO donation), producing profound vasodilation and potentially fatal hypotension.

What should I do if I'm prescribed both?

Combination is absolutely contraindicated. Wait at least 24 hours after sildenafil (48 hours for tadalafil) before administering any nitrate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.